姓名：吕波 职称：长聘副教授 导师类型：博士生/硕士生导师 团队名称：生物催化与合成生物系统团队 邮箱：lv-b@bit.edu.cn

研究领域

主要研究方向：数据驱动的新酶挖掘与理性设计，高附加值天然产物的改性与药效评价；稀有高值植物天然产物的细胞工厂的构建；高值天然产物的产业化示范线建设，生产工艺设计与工程化验证。

招生学科：药学、生物工程与技术、化学工程与技术、制药工程和化学工程方向，与清华大学化工系合成生物催化、绿色生物重点实验室联合培养。

教育经历

2009年09月–2015年01月：北京理工大学生物化工专业 博士学位

2006年09月–2009年07月：石河子大学，农产品加工及贮藏工程， 硕士学位

2002年09月–2006年07月：北京理工大学生物工程专业 学士学位

工作经历

2024年12月– 至今 ：北京理工大学化学与化工学院 长聘副教授

2018年9月–2024年11月 ： 北京理工大学化学与化工学院，预聘副教授

2015年10月–2018年9月 ： 北京理工大学化学与化工学院 博士后

学术成果

针对生物转化过程中附加值低、关键酶存在的底物特异性差、重复利用率低和生产成本高等问题，开发了10余种酶制剂改造与产业化应用，实现甘草次酸和甘草新苷、脱氢甘草亭酸等20多个衍生物的可控合成。主持并参与国家自然科学基金、科技部国家重点研发计划课题、企业横向课题和JKW项目等12项项目，以第一作者或通讯作者在Plant Comm、Chinese Chem Lett、Acta Pharm Sin B、Metab Eng、Int J Biol Macromol 、ACS Synth Biol 、Bioresource Technol和 Biotechnol Bioeng 等顶级期刊发表SCI文章40余篇，授权中国、日本专利等14项，参编教材2部。

近5年发表部分论文：

1. Ban Yali, Jiang Jixuan, Yang Hongwang, Jia Haiyang, Pang Yaru, Cheng Xu, Yan Jianbin, Liao Qinggang, Li Chun*, Lv Bo*, Feng Yongjun*. The complete synthetic pathway of echinacoside from Cistanche deserticola and its de novo biosynthesis in yeast. Plant Communications 2025 , 101430.

2. Zhang Yapeng, Liu Chenwen, Li Wenqiang, Ma Zhidong, Lv Bo*, Qin Lei*, Li Chun*. Systematic engineering of the sterol synthesis pathway for Saccharomyces cerevisiae promotes the efficient production of β-caryophyllene，Metabolic Engineering 2025,91:347-355.

3. Sun Wentao, Xiang Lin, Wang Runming, Huang Meilan, Lv Bo*, Hu Youcai, Li Chun*. Microenvironment accessibility enables rare oxidation type of triterpenoids by plant P450. Chinese Chemical Letters.2025: 110965.

4. Yapeng Zhang, Zhidong Ma, Wenqiang Li, Chenwen Liu, Huipeng Gao, Meng Wang, Lanpeng Li, Quan Zhang, Bo Lv*, Lei Qin*, Chun Li*. Dynamic regulation and enhancement of synthetic network for efficient biosynthesis of monoterpenoid α-pinene in yeast cell factory. Bioresource Technology, 2025,419: 132064.

5. Ban, Yali; Yang, Hongwang; Jiang, Jixuan; xia, Ting; Pang, Yaru; Cheng, Xu; Yang, Yixuan; Lv, Bo*; Feng, Yong-Jun*. A novel feruloyl esterase from Rehmannia glutinosa endophyte Alternaria botrytis RYF1 and its application in production of verbasoside and hydroxysalidroside. Journal of Agricultural and Food Chemistry 2025, 73, 8, 4725-4739.

6. Xinying Li, Jingnan Wang, Chang Su, Chao Guo, Zhouqin Xu, Kehui Wang, Jian Pang, Bo Lv*, Chao Wang*, Chun Li*. The PurR family transcriptional regulator promotes butenyl-spinosyn production in Saccharopolyspora pogona, Applied Microbiology and Biotechnology,2025, 109:14.

7. Lin Xiang, Wentao Sun, Siqin Zhang, Haocheng Zhang, Bo Lv*, Lei Qin*, and Chun Li*. Discovery, Biomanufacture and Derivatization of Licorice Triterpenoids. Journal of Agricultural and Food Chemistry,2025,73 (1), 4-29.

8. Wentao Sun, ShengtongWan, Chuyan Liu, Ruwen Wang, Haocheng Zhang, Lei Qin, Runming Wang, Bo Lv*, Chun Li*. Establishing cell suitability for high-level production of licorice triterpenoids in yeast. Acta Pharmaceutica Sinica B,2024,14(9):4134-4148.

9. Linhao Chen, Junjie Lai, Yan Luo, Tao Shu, Bo Lv*, Chun Li*. Efficient glycyrrhetinic acid biomanufacturing through protein engineering and dual-GUS combination strategy with novel β-glucuronidase from Aspergillus calidoustus CLH-22. Bioresource Technology, 2024, 413: 131436.

10. Yaru Pang, Xu Cheng, Yali Ban, Yue Li, Bo Lv*, Chun Li*. Efficient production of 22(R)-hydroxycholesterol via combination optimization of Saccharomyces cerevisiae. Biotechnology Journal,2024.19(7).

11. Ban Yali, Yang Hongwang, Jiang Jixuan,Wang Chengbin,Lv Bo*, Feng Yongjun*.A α-L-rhamnosidase from Echinacea purpurea endophyte Simplicillium sinense EFF1 and its application in production of Calceorioside B. International journal of biological macromolecules,2024,270:132090.

12. Cheng Xu, Pang Yaru, Ban Yali, Cui Shuai, Shu Tao, Lv Bo*, Li Chun*. Application of multiple strategies to enhance oleanolic acid biosynthesis by engineered Saccharomyces cerevisiae. Bioresource Technology,2024, 401: 130716.

13. Wan Shengtong; Liu Xia; Sun Wentao*; Lv Bo*; Li Chun*. Current advances for omics-guided process optimization of microbial manufacturing. Bioresources and Bioprocessing,2023, 10(1): 30.

14. Wang Ruwen; Liu Xia; Lv Bo*; Sun Wentao*; Li Chun*. Designing Intracellular Compartments for Efficient Engineered Microbial Cell Factories[J]. ACS Synthetic Biology, 2023, 12(5):1378-1395.

15. Sun Jiachen, Sun Wentao, Zhang Genlin*, Lv Bo*, Li Chun*. High efficient production of plant flavonoids by microbial cell factories: Challenges and opportunities. Metabolic Engineering,2022, 70, 143-154.

16. Zhang Teng, Sun Yi, Ma, Zhidong, Zhang Jinwen, Lv Bo*, Li Chun*. Developing iterative and quantified transgenic manipulations of non-conventional filamentous fungus Talaromyces pinophilus Li-93. Biochemical Engineering Journal,2022, 179, 108317.

17. Xu Ke, Zhao Yujia, Ahmad, Nadeem, Wang, Jinnan, Lv Bo*, Li Chun*. O-glycosyltransferases from homo sapiens contribute to the biosynthesis of glycyrrhizic acid 3-o-mono-β-d-glucuronide and glycyrrhizin in saccharomyces cerevisiae. Synthetic and Systems Biotechnology, 2021, 6(3), 173-179.

18. Chen L, Pang Y, Luo Y, Cheng X, Lv B*, Li C*, Separation and purification of plant terpenoids from biotransformation. Engineering in life sciences, 2021;1-15.

19. Haoran Liu, Nadeem Ahmad, Bo Lv*, Chun Li*. Advances in production and structural derivatization of the promising molecule ursolic acid [J]. Biotechnology Journal, 2021,16(11).

20. Liu Mingzhu, Yu Jing, Lv Bo*, Hou Yuhui, Liu Xinhe, Feng Xudong*, & Li Chun. Improving the activity and thermostability of GH2 β‐glucuronidases via domain reassembly. Biotechnology and Bioengineering, 2021, 118(5): 1962-1972.

教学工作

指导学生获国际遗传工程机器设计竞赛（iGEM）（2025金奖、最佳软件单项奖，最佳硬件提名，最佳赛道提名）和2020银奖、指导学生获2021年制药工程专业优秀本科毕业论文、国家奖学金、北京市优秀毕业生。主持教育部产学合作协同育人项目，参编“催化作用原理” 研究生精品网络共享课、 国家级网络课程，指导学生获得“ 挑战杯” 校级铜奖。

荣誉奖励

就业先进个人（2022）、优秀工会干部（2020）

社会兼职

合成生物学编委，中国食品药品绿色原料委员会顾问，北京微生物学会第十二届理事，中国生物发酵产业协会微生物育种分会第二届理事会理事。