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姓名:何治宇 职称:教授 导师类型:博导 团队名称:医用机器人与微系统创新团队 邮箱:zhiyuhe@bit.edu.cn hezhiyu@bitzh.edu.cn
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1. 应用于脑卒中、急性肝/肾损伤、急性胰腺炎、败血症等急性危重症疾病防治纳米药物的开发;
2. 口服多肽递送系统、多肽控/缓释递送系统的开发;
3. 纳米药物的工程转化技术的开发。
2016年12月~2017年6月 约翰霍普金斯大学医学院 访问学者
2014年08~2017年6月 中山大学中山医学院 博士
2011年8月~2014年7月 浙江工业大学药学院 硕士
2007年8月~2011年6月 蚌埠医科大学药学院 学士
2025年10月-至今 北京理工大学(珠海校区) 准聘教授
2020年3月-2025年9月 中国海洋大学 教授
2017年6月-2020年1月 约翰霍普金斯大学医学院 博士后研究员
学术成果:
回国独立开展工作以来,近5年以通讯作者身份在ACS Nano (4篇)、Adv. Sci. (2篇)、J. Control. Release. (3篇)、Chem. Eng. J. (3篇), Acta Biomater. (2篇)、Biomaterials等领域顶尖学术期刊上发表中科院 TOP 1区 SCI论文30余篇,累计影响因子 > 400,论文引用数超过2300次,H因子30,ESI高被引论文2篇,2023年获山东省“泰山学者”人才荣誉称号,第一申请人获授权专利7项, 主持和参与国家自然科学基金4项,主持海南省重点研发项目1项,企业横向1项。
独立开展工作后通讯作者论文(近3年,代表作10篇)
1. Wang Y, Pu M, Yan J, Zhang J, Wei H, Yu L*, Yan X, He Z*. 1, 2-Bis (2-aminophenoxy) ethane-N, N, N′, N′-tetraacetic acid acetoxymethyl ester loaded reactive oxygen species responsive hyaluronic acid–bilirubin nanoparticles for acute kidney injury therapy via alleviating calcium overload mediated endoplasmic reticulum stress[J]. ACS Nano, 2022, 17(1): 472-491. (IF:17.1 末尾通讯作者)
2. Wang Y, Wang X, Zhang X, Meng X, Qian D, Xu Y, Yu L*, Yan X, He Z*. Inflammation and Acinar Cell Dual-Targeting Nanomedicines for Synergistic Treatment of Acute Pancreatitis via Ca2+ Homeostasis Regulation and Pancreas Autodigestion Inhibition[J]. ACS Nano, 2024, 18(18): 11778-11803. (IF:17.1 末尾通讯作者)
3. Wang Y, Qian D, Wang X, Zhang X, Li Z, Meng X, Yu L, Yan X, He Z*. Biomimetic Trypsin-responsive structure-Bridged Mesoporous Organosilica Nanomedicine for precise treatment of acute pancreatitis[J]. ACS Nano, 2024, 18(29): 19283-19302. (IF:17.1 独立通讯作者)
4. Wang Y, Liu X, Li K, Wang X, Zhang X, Qian D, Meng X, Yu L, Yan X, He Z*. Self-Sulfhydrated, Nitro-Fixed Albumin Nanoparticles as a Potent Therapeutic Agent for the Treatment of Acute Liver Injury[J]. ACS Nano, 2024, 18(31): 20772-20791. (IF:17.1 独立通讯作者)
5. Yan J, Zhang J, Wang Y, Liu H, Sun X, Cui P, Yu L*, Yan X, He Z*. Rapidly inhibiting the inflammatory cytokine storms and restoring cellular homeostasis to alleviate sepsis by blocking pyroptosis and mitochondrial apoptosis pathways[J]. Advanced Science, 2023, 10(14): 2207448. (IF:15.1 末尾通讯作者)
6. Wang Y, Ma X, Wang X, Liu L, Zhang X, Wang Q, Zhu Y, Xu H*, Yu L, He Z*. Traditional Chinese Medicine Borneol‐Based Polymeric Micelles Intracerebral Drug Delivery System for Precisely Pathogenesis‐Adaptive Treatment of Ischemic Stroke[J]. Advanced Science, 2025: 2410889. (IF:15.1 末尾通讯作者)
7. Ma X, Zhang X, Wang Y, He Z*. Dynamic ROS-responsive hyperbranched polymer-based neuroprotective drug delivery system for pathogenesis-adaptive sequential therapy of cerebral ischemic stroke[J]. Biomaterials, 2025: 123683. (IF:13.0 独立通讯作者)
8. Wang Y, Wei H, Li K, Liu L, Zhu Y, Wang X, Yan J, Yu L*, Yan X, He Z*. Ros-responsive dextran-phenylboronic acid-silibinin nanoparticles for targeting delivery of BAPTA-AM to effectively eliminate calcium overload-mediated inflammatory cascades and mitochondrial apoptosis: Alleviating acute liver injury[J]. Chemical Engineering Journal, 2024, 480: 148283. (IF:15.1 末尾通讯作者)
9. Liu R, Yan J, Wang Z, Liu H, Ma X, Wang Y, Sun X, Zhang B, Zhang J, He Z*, Lu Y*. “Two-birds-one-stone” oral colon-targeted nanomedicine for ulcerative colitis precise therapy via remodeling inflammation microenvironment and inhibiting lipid peroxidation/ferroptosis [J]. Chemical Engineering Journal, 2025, 505: 159736. (IF:15.1 共同通讯作者)
10. Yan J, Sun X, Wang Y, Meng X, Liu H, Zhang B, Wang Q, Wei S, Ma X, Xu H*, Yu L, He Z*, Lu Y*. Two-pronged nanostrategy for treating ALI and blocking pulmonary fibrosis through intracellular/extracellular synergistic intervention to restore mitochondrial homeostasis and inhibit inflammation [J]. Chemical Engineering Journal, 2025, 506: 159903. (IF:15.1 末尾通讯作者)
山东省“泰山学者”青年专家
1. Chinese Chem. Lett. 杂志编委
2. Asian J. Pharm. Sci. 杂志编委
3.中国人体修复技术和材料创新联盟专家委员会委员
4. Nat. Commun., Nat. Biomed. Eng., ACS Nano, Nano Letters, Adv. Funct. Mater.等权威学术期刊的特约审稿人