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姓名：梁建华 职称：教授 导师类型：博导 团队名称：纳米生物医学与诊疗研究团队 邮箱：ljhbit@bit.edu.cn |
研究领域
抗耐药菌感染、抗病毒、抗炎镇痛、抗神经退行性疾病等重大疾病相关新药创制。目前主持参与国家研发重点计划项目、科技创新2030重大项目、国家自然科学基金、北京市自然科学基金等课题。
教育经历
1999/9—2004/3 博士，北京理工大学材料科学与工程学院（国防科工委优秀毕业生）
1995/9—1999/7 学士，北京理工大学化工与材料学院（北京市优秀毕业生）
工作经历
2004/4—至今 北京理工大学生命/化学与化工学院 讲师/副教授/教授/责任教授
2019/7—2020.8 访问教授，明尼苏达大学药学院, 合作教授：Aldrich Courtney
2010/4—2011.4 访问教授，普渡大学药学院, 合作教授：Mark Cushman
学术成果
迄今以通讯作者在 Nature Chem. Biol., Cell Disc., J. Med. Chem., Euro. J. Med. Chem., Bioorg. Chem., Curr. Med. Chem., Curr. Top. Med. Chem., Bioorg. & Med. Chem., Bioorg. & Med. Chem. Lett.等发表学术论文 40 多篇。
- Shehzadi Kiran, Ran Yue, Kalsoom Iqra, Dong Jingyue, Gao Peifeng, Muhammad Irfan *, Yu Ming-jia*, Meng Zihui*, Liang Jian-hua*. Structure-Informed Design of High-Cooperativity PROTAC Targeting SARS-CoV-2 RdRp via Click Chemistry and Enhanced Sampling Simulations. Journal of Medicinal Chemistry, 2026, 69, DOI: 10.1021/acs.jmedchem.5c02065
- Wang Zhen-Yue, Dong Jing-Yue, Jian-Hua Liang. Developments in small-molecule soluble epoxide hydrolase inhibitors: synthetic advances and therapeutic applications. Future Medicinal Chemistry, 2026, DOI: 10.1080/17568919.2025.2580912
- Ran Yue #, Li Sen #, Wang Ying-Jie, Liang Jian-Hua *, Jiang Wei *, Yu Ming-Jia *. AI-Accelerated Identification of Novel Antimicrobial Peptides for Inhibiting Fusarium graminearum. Journal of Agricultural and Food Chemistry, 2025, 73, 17471−17482. DOI: 10.1021/acs.jafc.5c03429
- Ding Jing,# Zhu Min-Zhen,# Du Xiao-Yu, Liu Si-Meng, Wang Hao,* Liu Xing-Zhou, Xie Wei-Song, Ma Hong-Le, Feng Yue*, Zhu Xin-Hong*, Liang Jian-Hua*. Discovery of Phenylacylpiperidine as Novel sEH Inhibitors through Scaffold Hopping of Natural Stilbene. Journal of Medicinal Chemistry, 2025, 68(8): 8980-9013., DOI: 10.1021/acs.jmedchem.5c00685
- Liu Xing-Zhou#, Du Xiao-Yu#, Xie Wei-Song#, Ding Jing#, Zhu Min-Zhen, Feng Zi-Qiang, Wang Hao, Feng Yue*, Yu Ming-Jia*, Liu Si-Meng, Liu Wen-Tian, Zhu Xin-Hong*, Liang Jian-Hua*. Redesigning Berberines and Sanguinarines to Target Soluble Epoxide Hydrolase for Enhanced Anti-Inflammatory Efficacy. Journal of Medicinal Chemistry, 2024, 67(24): 22168−22190, DOI: 10.1021/acs.jmedchem.4c02202
- Liu Qian #, Wang Yi-Xin #, Ge Zi-Hao #, Zhu Min-Zhen #, Ding Jing, Wang Hao, Liu Si-Meng, Liu Rui-Chen, Li Chun, Yu Ming-Jia, Feng Yue *, Zhu Xin-Hong *, Liang Jian-Hua *. Discovery of glycosidated glycyrrhetinic acid derivatives: natural product-based soluble epoxide hydrolase inhibitors. European Journal of Medicinal Chemistry, 2024, 280: 116937, DOI: 10.1016/j.ejmech.2024.116937
- Ding Jing, Zhu Min-Zhen, Liu Si-Meng, Liu Rui-Chen, Xu Shuo, Shehzadi Kiran, Ma Hong-Le, Yu Ming-Jia*, Zhu Xin-Hong*, Liang Jian-Hua*. Discovery of Orally Active Phenylquinoline-based Soluble Epoxide Hydrolase Inhibitors with Anti-inflammatory and Analgesic Activity. Journal of Medicinal Chemistry, 2024, 67(20):18412-18447, DOI：10.1021/acs.jmedchem.4c01766
- Zhang Na #, Liu Wen-Tian #, Cui Xin-Yi, Liu Si-Meng, Ma Cong-Xuan, Liang Jian-Hua *. Design and Structure-Activity Relationships of Ether-linked Alkylides: Hybrids of 3-O-Descladinosyl Macrolides and Quinolone Motifs. Bioorganic Chemistry. 2024, 151，107712. DOI: 10.1016/j.bioorg.2024.107712
- Aleksandrova Elena V. #, Ma Cong-Xuan #, Klepacki Dorota #, Alizadeh Faezeh, Vázquez-Laslop Nora, Liang Jian-Hua *, Polikanov Yury S. *, Mankin Alexander S. *. Macrolones target bacterial ribosomes and DNA gyrase and can evade resistance mechanisms. Nature Chemical Biology, 2024, 20; 1680–1690. DOI: 10.1038/s41589-024-01685-3
- Ma Cong-Xuan #, Li Ye #, Liu Wen-Tian, Li Yun, Zhao Fei, Lian Xiao-Tian, Ding Jing, Liu Si-Meng, Liu Xie-Peng, Fan Bing-Zhi, Liu Li-Yong, Xue Feng, Li Jian, Zhang Jue-Ru, Xue Zhao, Pei Xiao-Tong, Lin Jin-Zhong *, Liang Jian-Hua * Synthetic macrolides overcoming MLSBK-resistant pathogens. Cell Discovery, 2024, 10. 75. DOI : 10.1038/s41421-024-00702-y
- Ma Cong-Xuan, Liu Wen-Tian, Li Xue-Meng, Ding Jing, Liu Si-Meng, Xue Feng, Li Yun,* Liang Jian-Hua.* Design, synthesis and structure-activity relationships of novel non-ketolides: 9-Oxime clarithromycin featured with seven-to thirteen-atom-length diamine linkers at 3-OH. European Journal of Medicinal Chemistry, 2024, 276, 116630. DOI: 10.1016/j.ejmech.2024.116630
- Feng Zi-Qiang, # Ding Jing, # Zhu Min-Zhen, # Xie Wei-Song, Liu Rui-Chen, Liu Si-Si, Liu Si-Meng, Yu Ming-Jia, * Zhu Xin-Hong * Liang Jian-Hua *. Discovery of a novel lead characterized by a stilbene-extended scaffold against sepsis as soluble epoxide hydrolase inhibitors. European Journal of Medicinal Chemistry, 2024, 266, 116113. DOI：10.1016/j.ejmech.2023.116113